Standardization

Pharmacological activity

MACA (Lepidium Meyenii)

• Energizer containing a considerable quantity of bioavailable iron;
• Supports iron absorption

STINGING NETTLE (Urtica Dioica)

• Hemostatic, antianemic and mineral provider.

CASCARA SAGRADA (Rhamnus Purhiana)

• Cleans the digestive system and is a natural laxative;
• Stimulates digestive secretions and allows a better mineral absorption

VITAMIN C (Ascorbic Acid)

• Preventive or prolonged use (chronic anemia): Take 1 tablespoon (15 ml) once a day during 1 to 6 months.
• Severe women anemia: Take 1 tablespoon (15 ml), twice a day during 1 month, then do as the prolonged use.

• Hematonik contains more than 250 mg of iron element and may cause serious prejudice to a child.
• FOR ADULTS ONLY. Keep out of reach of children.
• Men should only  take this product under the supervision of a health practitioner.

• Suffer from anemia;
• Present an iron or trace mineral deficiency, vitamins B1, B6, B12, C or folic acid deficiency;
• Feel weak, lack  energy or those who are recovering from an illness;
• Suffer from chronic hemorrhages (blood loss);
• Follow a vegetarian or vegetalian diet;
• The elderly who have difficulty absorbing food  produced iron.

CONTRAINDICATIONS

• Reserved exclusively for adults.
• Keep out of reach of children.

PRECAUTIONS

• Consult a health practitioner in case of edema or a disordered metabolic state (Wilson’s disease);
• Cease the use and consult a health practitioner if the symptoms persist or if undesirable effects should occur.
• This product is inadvisable in case of bowel obstruction, cancer or skin infections;
• Avoid consuming with any kind of tea 1 hour before or 1 hour after taking Hematonik. It may affect iron absorption.

MEDICINAL INTERATIONS

• Decreases therapeutic effects of Levodopa (Parkinson’s Disease), phenytoin (epilepsy);
• Interaction with tetracycline, corticosteroid, hypotensive agents (increases the effects);
• Potentiates the effects of anti-inflammatory and sedatives medications;
• Increases the diuretic and laxative effects. A dose adjustment is necessary;
• Additive effect to natural laxatives (senna, rhubarb, etc);
• May increase the effects of cardiac anti-arrhythmic agents through intervening with intracellular K+ level;
• May reduce the absorption of certain medications because of its laxative effects;
• The simultaneous intake of amiodarone (cardiac arrhythmia) can increase the risk of photosensitivity;
• Vitamin C (more than 1000 mg per day) may interact with Warfarin (Coumadin®, anticoagulant) by reducing its absorption;
• In the event of serious disease or consumption with other medications, do not take this product without the consent of an expert healthcare professional.

SIDE EFFECTS

• Reddish-brown urine coloring;
• Abdominal cramps, nausea, diarrhea and hyperkalemia (high potassium concentration in blood) if used in very strong doses;
• Occasionally, temporary skin eruptions due to vitamin B6, in the form of vasomotor flushing: redness of the face and neck and a burning sensation in the hands and feet.

SPEED OF THE EFFECT

• The effect that is immediately felt after absorption, may cause a short-term skin reaction, similar to an allergy such as redness on the trunk, face, neck and limbs. This reaction is unpleasant, but is not dangerous and is temporary. It is necessary to be patient as this effect will last from 5 to approximately 20 minutes;
• After 1 week of treatment, fatigue will gradually decrease and after one month, you will feel a true difference. However, you should not stop using the product if, at the beginning of the treatment period you feel other symptoms such as accentuated paleness of the mucous membrane, palpitations, nervous or pulmonary disorders; because the short-term treatment, is at that time, only a temporaty source of the missing substances. A long-term use will fulfill the stockage zones;
• In serious cases, with obvious complications, neurological symptoms will disappear at the end, after 6 months of continuous treatment.

SYNERGISTIC ACTIONS

• Iron, copper, vitamins B1, B6, B9 and B12 are crucial factors in the formation of red blood cells;
• Several ingredients act interdependently: vitamins B6, B9 and B12 take part in the homocysteine metabolism. The homocysteine is an important aminoacid in the myelin production, which is some kind of an insulating sleeve around the nerves;
• Copper and vitamin C are very good antioxidants;
• In general, iron supplementation causes constipation. The addition of Cascara Sagrada has a laxative effect in our formulation, it prevents the appearance of this disadvantage, without modifying anything in the absorption of other components in our product.

• Stinging nettle and maca are great sources of trace minerals and vitamins of which are folic acid, B vitamins complex, iron and copper. They are important in the formation and the function of red blood cells and hemoglobin. These plants are also important energy suppliers, by decreasing the side effects due to anemia, fatigue or depression;
• The stinging nettle contains a large concentration of gallic acid, which enables it to stop small hemorrhages associated with certain chronic diseases: uterine fibroma, gingivitis and gastric ulcers. It may be used during pregnancy and even during breastfeeding, thanks to its effect in supporting storage of vitamin K and in stimulation of lactation, while giving an extra dose of energy to new moms

• Cutler P. Deferoxamine therapy in high-ferritin diabetes. Diabetes 1989;38:1207-10.
• Stevens RG, Graubard BI, Micozzi MS, et al. Moderate elevation of body iron level and increased risk of cancer occurrence and death. Int J Cancer 1994;56:364-9.
• Weinberg ED. Iron withholding: a defense against infection and neoplasia. Am J Physiol 1984;64:65-102.
• Favier. A. Actualités sur la place du Zinc en nutrition. Rev.Prat 1993, 43, 2 : 146-151.
• Van Caillie-Bertrand M. Métabolisme des micronutriments. Traité de nutrition pédiatrique édition Maloine 1993, 6 : 177-182. in Ricour C, Ghisolfi S, Putet G, Goulet O. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline, 2000. Food and Nutrition Board, Institute of Medicine.
• Blumenthal M, Goldberg A, Brinckmann J (Ed). Expanded Commission E Monographs, American Botanical Council, published in collaboration with  Integrative Medicine Communications, United States, 2000.
• Ernst Edzard (Ed). The Desktop Guide to Complementary and Alternative Medicine, Mosby, Great Britain, 2001.
• European Scientific Cooperative on Phytotherapy (Ed). Urticae folium/herba + Urticae radix ESCOP Monographs on the Medicinal Uses of Plants Drugs, Centre for Complementary Health Studies,  Exeter University, Great Britain, 1996, 1997.
• Integrative Medicine Communications (Ed). Clinical reference, Herbs -Stinging Nettle, Onemedicine.com. www.onemedicine.com.
• Therapeutic Research Faculty (Ed). Stinging nettle above ground parts + Stinging nettle root, Natural Medicines
• Comprehensive Database. www.naturaldatabase.com
• See monograph of the Government of  Canada. http://www.hc-sc.gc.ca/hpfb-dgpsa/nhpd-dpsn/mono
• ConsumerLab. Product Review: Sexual Enhancement Supplements (Including L-Arginine, Yohimbe, and Epimedium (Horny Goat Weed)). http://consumerlab.com/.
• Taylor L. Herbal Secrets of the Rainforest, Sage Press, United States, 2002. http://www.rain-tree.com/.
• Leon, J. 1964. The "maca" (Lepidium Meyenii) a little known food plant of Peru. Economic Botany. 18:122-127.
• DerMarderosian A et al. Maca, The Review of Natural Products - Facts and Comparisons, United States, 1999.
• Therapeutic Research Faculty (Ed). Maca, Natural Medicines Comprehensive Database. www.naturaldatabase.com.
• Madelin Erica. Global warming threat to rhubarb. Morleytoday.co.uk United Kingdom. www.morleytoday.co.uk.
• Purdue University. Rhubarb. Entm.purdue.edu www.entm.purdue.edu.
• Rhubarbinfo. The Rhubarb Compendium. Rhubarbinfo.com www.rhubarbinfo.com.
• Royal Horticultural Society. Chilling news about fruit and veg. Rhs.org.uk www.rhs.org.uk. http://www.pdrhealth.com/drug_info/nmdrugprofiles/herbaldrugs/102380.shtml.
• Belaiche P, Lievoux O. Clinical Studies on the Palliative Treatment of Prostatic Adenoma with Extract of Urtica Root. Phytotherapy Res. 1991;5:267-269.
• Blumenthal M, ed. The Complete German Commission E Monographs. Therapeutic Guide to Herbal Medicines. Boston, Mass: Integrative Medicine Communications; 1998:47, 132.
• Bradley P, ed. British Herbal Compendium. Dorset, England: British Herbal Medicine Association; 1992;1:166-167.
• Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, Ore: Eclectic Medical; 1998:125.
• Chrubasik S, Enderlein W, Bauer R, Grabner W. Evidence for antirheumatic effectiveness of Herba Urticae dioica in acute arthritis: A pilot study. Phytomedicine. 1997;4:105-108.
• Grieve M. A Modern Herbal. New York, NY: Dover; 1971;2:574-579
• Gruenwald J, Brendler T; Christof J. PDR for Herbal Medicines. Montvale, NJ: Medical Economics Company; 1998:1197-1199.
• Hutchens A. Indian Herbalogy of North America. Boston, Mass: Shambhala; 1991:204-206.
• Krzeski T, Kazon M, Borkowski A, Witeska A, Kuczera J. Combined extracts of Urtica dioica and Pygeum africanum in the treatment of benign prostatic hyperplasia: double-blind comparison of two doses. Clin Ther. 1993;15:1011-1020.
• Millspaugh C. American Medicinal Plants. New York, NY: Dover; 1974:611-614.
• Newall C, Anderson L, Phillipson J. Herbal Medicines: A Guide for Health-Care Professionals. London, England: Pharmaceutical Press; 1996:201-202.
• Obertreis B, Giller K, Teucher T, et al. Antiphlogistic effects of Urtica diocia folia extract in comparison to malic acid. Arzneim-Forsch. 1996;46:52-56.
• Obertreis B, Rutkowski T, Teucher T, et al. Ex-vivo in-vitro inhibition of polysaccharide-stimulated tumor necrosis factor-a and interleukin-1b secretion in human whole blood by extractum Urticae dioicae foliorum. Arzneim-Forsch. 1996;46:389-394.
• Oliver F, Amon E, Breathnach A, Francis D, Sarathchandra P, Black A, Greaves M. Contact urticaria due to the common stinging nettle (Urtica dioica-histological, ultrastructural and pharmacological studies. Clin Exp Dermatology. 1991;267:1-7.
• Schneider H, Honold E, Masuhr T. Treatment of benign prostatic hyperplasia. Results of a treatment study with the phytogenic combination of Sabal extract WS 1473 and Urtica extract WS 1031 in urologic specialty practices. Fortschr Med. 1995;267:37-40.
• Schulz V, Hänsel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. 3rd ed. Berlin, Germany: Springer-Verlag; 1998:228-238.
• Schottner M, Gansser D, Spiteller G. Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG). Planta Med. 1997;63(6):529-532.
• Teucher T, Obertreis B, Rutkowski T, et al. Cytokine secretion in whole blood of healthy volunteers after oral ingestion of an Urtica dioca L. leaf extract. Arzneim-Forsch. 1996;46:906-910.
• Tyler VE. Herbs of Choice: The Therapeutic Use of Phytomedicinals. Binghamton, NY: Haworth; 1994:84-85.
• Wylie G, et al. A comparative study of Tenidap, a cytokine-modulating anti-rheumatic drug, and diclofenac in rheumatoid arthritis: a 24 week analysis of a 1-year clinical trial. Br J Rheumatol. 1995;34:554-563.
• National Academy of Sciences. Lost Crops of the Incas: Little-Known Plants of the Andes with Promise for Worldwide Cultivation. Office of International Affairs (OIA), États-Unis, 1989. http://books.nap.edu/Therapeutic Research Faculty (Ed). Maca, Natural Medicines Comprehensive Database. www.naturaldatabase.com
• Taylor L. Herbal Secrets of the Rainforest, Sage Press, États-Unis, 2002. http://www.rain-tree.com/
• Cicero AF, Bandieri E, Arletti R. Lepidium meyenii Walp. improves sexual behaviour in male rats independently from its action on spontaneous locomotor activity.J Ethnopharmacol. 2001 May;75(2-3):225-9.
• Cicero AF, Piacente S, Plaza A, Sala E, Arletti R, Pizza C. Hexanic Maca extract improves rat sexual performance more effectively than methanolic and chloroformic Maca extracts.Andrologia. 2002 Jun;34(3):177-9.
• Gonzales GF, Ruiz A, Gonzales C, Villegas L, Cordova A. Effect of Lepidium meyenii (maca) roots on spermatogenesis of male rats.Asian J Androl. 2001 Sep;3(3):231-3.
• Gonzales GF, Cordova A, Vega K, Chung A, Villena A, Gonez C, Castillo S. Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men. Andrologia. 2002 Dec;34(6):367-72.
• Gonzales GF, Cordova A, Vega K, Chung A, Villena A, Gonez C. Effect of Lepidium meyenii (Maca), a root with aphrodisiac and fertilityenhancing properties, on serum reproductive hormone levels in adult healthy men.J Endocrinol. 2003 Jan;176(1):163-8.
• Actionaid. Peruvian's love root under threat. http://www.actionaid.org/Fogelholm M, Rehunen S, Gref CG, Laakso JT, Lehto J, Ruokonen I Himberg JJ. Dietary intake and thiamin, iron, and zinc status in elite Nordic skiers during different training periods. Int J Sport Nutr. 1992 Dec;2(4):351-65.
• Suzuki M, Itokawa Y. Effects of thiamine supplementation on exercise-induced fatigue. Metab Brain Dis. 1996 Mar;11(1):95-106.
• Aybak M, Sermet A, Ayyildiz MO, Karakilcik AZ. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995 Dec;45(12):1271-3.
• Rimm EB, Willett WC, Hu FB, Sampson L, Colditz GA, Manson JE, Hennekens C, Stampfer MJ. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women. JAMA. 1998 Feb 4;279(5):359-64.
• Adachi S, Kawamoto T, Otsuka M, Todoroki T, Fukao K. Enteral vitamin B12 supplements reverse postgastrectomy B12 deficiency. Ann Surg. 2000 Aug;232(2):199-201.
• Grange DK, Finlay JL. Nutritional vitamin B12 deficiency in a breastfed infant following maternal gastric bypass. Pediatr Hematol Oncol. 1994 May-Jun;11(3):311-8.
• Quinn K, Basu TK. Folate and vitamin B12 status of the elderly. Eur J Clin Nutr. 1996 Jun;50(6):340-2.
• Weir DG, Scott JM. Brain function in the elderly: role of vitamin B12 and folate. Br Med Bull. 1999;55(3):669-82.
• Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):7915-22.