Standardization

Plant / Ingredient	Standardization	Quantity of dried plant per 7,5 ml
Rice germ	GABA 40 %	1000 mg (germs)
Valerian	Valerique acid 0,6 %	600 mg (roots)
Griffonia	5-HTP 5 %	575 mg (seeds)
Hot	Flavonoids 1 %	300 mg (cones)
Yuzu	Limonoids 0,2 %	50 mg (seeds)
Inositol	S/O	50 mg

Pharmacologics activity

Naturel products and plants in this formulation are traditionnaly used for the following effects:

VALERIAN (Valeriana officinalis)

Origin : Canada

• Hypnotic (inducer of sleepl) ;
• Sedative and antidepressant.

GRIFFONIA (Griffonia simplicifolia)

Origin : Africa

• Provide 5HTP in the body;

• Stimulate the production of serotonin;

• Control the activities of the pituitary gland;

• Prevent the harmful effects of cortisol.

HOP (Humulus lupulus )

Origin : Europa

• Relaxant, hypnotic and sedative;

• Support digestion.

RICE GERM (Oryza sativa)

Origin : Asia

• Supplies GABA to the body, allowing neurotransmitter to permit relaxation;
• Inhibiting role in the apparition mechanism of stress;
• Psychic and physical tranquillizer;
• Repair agent for the quality of sleep.

INOSITOL

• Anxiolytic, antidepressant et sedative.

YUZU (Citrus junos)

Origin : Japan

• Stimulate memory and support concentration.
• Mild relaxant.

Somny Z may be used in different ways:

• Prolonged use (chronic insomnia): Take 1½ teaspoon (7,5 ml) at least 1 hour before bedtime during 1 month. Progressively reduce dosage before ending the treatment.

• Occasional use (transitory insomnia): About one hour before bedtime, take 1½ teaspoon (7,5ml) (with a small amount of juice) and keep under the tongue for a minimum of 30 to 60 seconds, then swallow. Take 1½ teaspoon more (same manner) just before bedtime.

When: Take at least 20 minutes or 1 hour before bedtime.
How: Shake the bottle and mix with juice.

*Refrigerate after opening.

SPEED OF EFFECT

• It is advised to take Somny Z from 15 to 60 minutes before bedtime, only one dose is often sufficient. Most people will see an improvement of sleep quality in 2 to 3 days;
• Average time to obtain relief from insomnia, i.e. fall asleep more quickly and be able to sleep a greater number of hours without waking up, will be from about 2 to 7 days.

Somny Z is given to those who:

• Suffer from chronic or transitory insomnia;
• Want to decrease chronic stress and accumulated tiredness;
• Wish to regulate the mechanism implied in the good function of the sleep-awake circadian rhythm;
• Wish to increase their quality of sleep in the long term;
• Suffer from stress and anxiety;
• Wish to sleep restfully without feeling tired when the alarm clock hits;
• Wish to improve memory by favoring deep sleep.

Synergic Action

The components of Somny Z act in complete synergy to regulate the mechanisms in good circadian rhythm sleep-awakening patterns.

The plants in our formulation have sedative and relaxing effects on the nervous system:

• Valerian: two categories of its components were proposed to be the primary sources of the sedative effects of valerian. The first category comprises the principal components of its volatile oils, including valeric acid and its derivatives, which have shown their sedative properties in animals. The second category comprise of iridoids, including valeprotriates. The latter and their derivatives act in vivo like sedatives, but are unstable and break up during storage or in an aqueous environment thus making their activity difficult to evaluate.

• Hop: In ethnobotany, hops are recognized for their soft sedative properties. Volatile oils, humulene, β-caryophyllene and valeric acid, etc, of hops are responsible for the hypnotic and sedative action. The majority of the medicinal plant preparations to counter insomnia, mix hop with other more effective sedative plants such as valerian to potentate their effect. It is a good combination because hops have the capacity to soften the effects of valerian, in order to prevent addiction to it;

• Inositol: Studies have showed that strong amounts of inositol can be beneficial in the treatment of depression, anxiety disorders, without the side effects of prescription drugs;
• Yuzu: More recent studies in human have showed that this plant can act by calming the nervous system. Its impact is visible by encephalogram via the alpha waves which are waves of relief in the brain. This property has an impact on the capacity of concentration and the maintenance of mental serenity.

• GABA: The modulating effects of GABA’s action, inductor of sleep: Rice germs are a direct source of GABA. Valerian may cause sedation because of the quantity of GABA it contains;

• Natural serotonin precursor is in charge of the awake-sleep mechanism, i.e. the internal clock which decides when and how it is necessary to sleep and when to wake up.

It is shown that the use of 5-HTP brings results as equal or improved as those of synthetic standard drugs used in the treatment of serotonin deficiency. Moreover, this 5-HTP from this origin, more easily passes the blood brain barrier (hemato-encephalic) to supply the chemical serotonin precursor. In Europe, it has been approved for decades in the treatment of depression, sleep disorders, weight loss and other medical problems. Clinical tests prove that it is a safe and natural manner to increase serotonin level in the brain. Its use implies not only the solution of insomnia, but also its great capacity to improved sleep quality.

Clinical studies prove that 5-HTP is useful in the treatment of sleep disorders other than insomnia. It increases REM sleep significantly, specifically by approximately 25%, whereas simultaneously, it increases paradoxical sleep of stages 3 and 4, without increasing the total sleep period. 5-HTP shortens the time in stages 1 and 2 of sleep, which are the least important stages of the cycle. The more the amount is important, the more time will lengthen in REM. By shifting the balance of the sleep cycle, the treatment will become restful and regenerating. Instead of feeling tired and dissatisfied, people who use this natural product feel impassioned, quite rested and ready to take up the daily challenges.

• Other effects on active processes, especially during sleep:

Inositol plays an important role in the health of cellular membranes and the intracellular transport, of which the calcium transport; particularly in specialized cells of the brain and spinal cord, which maintain the vitality of the central nervous system. Another role of inositol in lecithin formation, is that of the metabolism of fats and cholesterol, which facilitates the transformation of fats into energy and glucose which are the essential nourishment for the brain mechanism; a very active process during sleep;

Yuzu acts on the peripheral blood circulation level, by increasing blood flow to the brain. It also has an important cellular regenerative effect in the aging process.

Q. Can Somny-Z cause addiction like the majority of other products that fight insomnia?

A. Absolutely not. Because there are many molecules that function synergistically, the body and brain will not adapt to this product. In addition, after a few weeks of use, the body relearns to produce good amounts of neurotransmitters, therefore decreasing the accumulated stress. The majority of people may stop the use of Somny-Z without having any problems involving sleep.

Q. Can sleep be affected by menopause?

A. Women complain more than men of fatigue and other difficulties connected to lack of sleep. These complaints are more prevalent among women who are over 40 years old. However, objective measurements in laboratory studies of sleep-awake cycles showed a different response: Sleep in men seems to weaken before that of women. Between 47 and 64% of menopausal women had difficulty sleeping and more than half of them felt tired. In addition, lack of sleep and tiredness may exacerbate changes of mood among many menopausal women.

Q. Why do the elderly have trouble sleeping?

A. Between 20% and 37% of the elderly complain about sleeping problems and feel less alert as well as vigilant during the day. Objective recordings in the laboratory of sleep-awake cycles showed that there was a difference between the elderly and younger people. The elderly sleeps earlier at night and awakes earlier in the morning, experiences a shorter duration of stages 3 and 4 deep sleep, and an increase in stages 1 and 2 of light sleep. Their hours of sleep are shorter and they are awoken more frequently, especially during the second half of the night. This “fragility” of sleep may explain why so many elderly people complain of somnolence during the day and tends to take more naps than younger people. Contrary to belief, changes of sleep start well before the age of 60 years old. It is a part of adult life that ones begin with sleeping less. It is indeed from the middle of adult life that we start with less better sleep.

Immediate benefits:

• Relaxation;
• Relief of stress and accumulated tiredness during the day;
• Helps to fall asleep and sleep throughout the night without feeling tired early in the morning.

Long-term effectiveness:

• Regulation of circadian rhythm (awake-sleep);
• Abolition of chronic stress;
• Long term increase in the quality of sleep;
• Increase in the capacity to concentrate;
• Improvement of the memorization by supporting deep sleep.

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Here are combinations of products suggested for individuals suffering from the following problems:

• Stressful living conditions: Relaximum helps to fight tension and symptoms of stress thus helping to provide a much more peaceful sleep and rest. It is a remarkable adjunct therapy to Somny-Z.

• For women: Sleep disturbances and anxiety: when a woman suffers from symptoms associated with menopause, her sleep, mood, etc. are disturbed. Flash-Meno assists by bringing a more refreshing sleep by reducing these disadvantages.