Standardization

Plant / Ingredient	Standardization	Dry plant qty per 7,5 m
Garcinia	HCA 5%	665 mg (fruits)
Primerose	Polyphenols 5%	300 mg (seeds)
Rhodiola	Rosaline 0,5 %	300 mg (fruits)
Banaba	Corosolic Acid 1%	200 mg (leaves)
Calcium	Chelated with amino acids	200 mg
Fibers	N/A	200 mg
Hoodia	Glycoside steroidal	200 mg (leaves)
Coleus	Forskolin 0,3%	50 mg (roots)
Cayenne Pepper	Capsaicine 0,1%	20 mg (fruits)

Pharmacological activity

Recognized traditional use.

CAMBODIA GARCIANA (Garcinia Cambogia)

Origin: Asia

• Slows down the synthesis of fats and regularizes appetite;
• Restricts carbohydrates (sugars) transformation into fat.

PRIMROSE (Oenothera Biennis)

Origin: North America

• Diabetes and obesity prevention;
• Insulin level stabilization and antioxidant;
• Important source of linolenic acid (essential fat acid).

RHODIOLA (Rhodiola Rosea)

  Origin: Russia

• Mobilizes the reserves of fats;
• Improves memory and decreases stress.

BANABA (Lagerstroemia Speciosa)

Origin: Philippines

• Regularizes the secretion and the blood level of insulin;
• Controls food cravings, especially those for carbohydrates;
• Contributes to weight loss.

CALCIUM (Chelated with amino acids)

• Controls the circulation of liquids towards the cells;
• Plays a role in weight maintenance.

HYDROSOLUBLE VEGETABLE FIBERS

• Improve the intestinal transit moment;
• Help control the cholesterol level;
• Sustain nutrients absorption.

HOODIA (Hoodia Gordonii)

• Has remarkable psycho-stimulant appetite suppressant properties;
• Gives a feeling of satiety by telling the brain that the body is well fed;
• Helps reduce the caloric intake and body mass;
• Stimulates the production of lean muscular mass.

COLEUS (Coleus Forskoliin)

• Regularizes intracellular metabolism;
• Stimulates the functions of the thyroid.

CAYENNE PEPPER (Capsicum Frutescens)

• Decreases the effectiveness of ingested calories and burns fat;
• Supports the digestion and decreases the appetite.

Metabotonik may be used in several ways and in different occasions:

• For daily prolonged use or to maintain weight: Take 1½ teaspoon (7,5 ml) once daily.
• To start a low calorie diet or for an appetite suppressant effect: Take 1½ teaspoon (7,5 ml) 3 times a day: morning, noon and night, at least 20 minutes before or 1 hour after a meal, during 1 month.

When: Take while eating or immediately after a meal (during prolonged use).
Usage: Shake well before using and mix with juice.

*Refrigerate after opening.

Metabotonik is recommended to all those who:

• Need to start a weight loss diet;
• Are constantly hungry;
• Have overweight problems and want to regularize their weight;
• Wish to accelerate their metabolism because they are overweight despite their low calorie intake;
• Need to regularize the function of their thyroid.

CONTRAINDICATIONS

• Allergies to the ingredients of the present formulation. People allergic to latex or tropical fruits such as bananas or kiwis, may be allergic to this product;
• Avoid giving to pregnant or breastfeeding women;
• Avoid giving in case of: serious pathologies (liver, kidneys), diabetes, hypoglycemia, epilepsy, mania and/or schizophrenia, bipolar disorder, digestive disorder.

PRECAUTIONS

Consult a health practitioner in case of:

• If you are currently taking black cohosh and Chasteberry (plants);
• Exclusively reserved to adults;
• Before combining with another product or medication;
• Cease the use and consult a health practitioner if the symptoms persist or if undesirable effects should occur.

MEDICINAL INTERACTIONS

• Do not use Metabotonik with other drugs without medical advice.
• Metabotonik should not be consumed without medical advice, with any other medicine, nor with any of the following medications :
• Stimulants such as amphetamines, hydralazine (for hypertension), beta-blocking agents, anticoagulants (Warfarin, Heparin, Plavix, Ticlid, Trental), antipsychotics (Lithium, AINS, Phenothiazine), anticonvulsants (Clonidine), AIS (corticosteroids);
• In the event of a serious disease or consumption with other medications, do not take this product without the consent of an expert healthcare professional.

SIDE EFFECTS

The following symptoms may appear if dosages are not respected:

• Headaches, fatigue, dizzy spells, gastro-intestinal pains;
• Excitement, agitation or insomnia may appear if taken in high dosages;
• Avoid taking in the evening to avoid sleep disturbance;
• May constipate by mechanical blockage if the fluid intake (water) is insufficient.

SPEED OF THE EFFECT

An effect can be observe after only a few days. Metabotonik will have an influence on weigh, but it is not a weight loss product. The effect is due to its impact on the metabolism. The thermogenic activity (energy supplier) and the affect on the thyroid hormones accelerate the metabolism and help the body to burn fats and spend more calories. Normally, the weight loss will be of approximately 500 g (1 pound) per week, depending on the initial weight of the person. The greatest advantage of Metabotonik is that the weight loss is slow; it will thus be much easier to maintain the new weight on a long-term period. After one month of use, general physical status should be improved.

SYNERGISTIC ACTION

The secret of this formulation lies in the combination of thermogenic, energy-giving, tonic, adaptogen and hormonal plants. They are plants acting as hormone regulators, particularly the thyroid hormones, as well as plants containing antioxidants.

This metabolism tonic will help to:

• Decrease the transformation of carbohydrates into fat;
• In addition in lowering the cholesterol and triglycerides levels and of its appetite suppressor action, garcinia helps to slightly stabilize insulin levels with the HCA that it contains;
• Primrose helps to control diabetic neuropathy;
• Rhodiola allows to reduce fatigue;
• Banaba is used in the treatment of diabetes and to purify the liver. It also helps to reduce blood glucose levels through “insulin-like principle”;
• Calcium intervenes in multiple ways: neuromuscular excitability, nerve conduction, muscle contraction, hormone release, enzyme activation, blood pressure control;
• Water soluble vegetable fibers improve intestinal transit time, help to control cholesterol levels and support absorption of nutrients;
• Hoodia joins the formulation for its properties to cut psychostimulant appetite suppressor, thus allowing the brain to send the message to the body that it is well nourished. It helps to reduce caloric intake and decreases the body mass index;
• Coleus forskholii has cardio-tonic properties. It can be used in food supplements aiming “slimness”, by its action on sugar and fat metabolisms.
• Cayenne pepper is a thermogenic stimulant, it has a beneficial effect on the metabolism of fats, the basal energy expenditure and the appetite control. It is also used to stimulate digestion, lower the accumulation of fats and bad cholesterol (LDL), and accelerates lipolysis (coleus, cayenne pepper, chelated calcium);
• Nourish capillary and cell membranes with bioflavonoids;
• Feel an increase in energy. Metabotonik improves the Net Energy Quotient (NEQ) of food, essential energy and glucose conversion, fatty acids and other energy sources in adenosine triphosphate (ATP), which is the main cellular source of energy;
• Stimulate basal metabolism. Physiological impact consists of increasing caloric expenditure; we can then observe a slight reduction but regular weight loss;
• Regulate the thyroid gland function. It has an impact on the management of weight, on the energy level and the quality of sleep.

Q.    Can Metabotonik be harmful for my health?

• http://pharma-help.com/coleus-forskohlii. Forskolin is a potent activator of the enzyme adenylate cyclase, which activates cyclic adenosine monophosphate (cAMP) in the cell. Through a multi-step process, this increases the concentration of the active form of hormone-sensitive lipase, resulting in a greater release of fatty acids from the body's adipose tissues. Forskolin also has a thyroid-stimulating action, which contributes to thermogenesis and an increase in the basal metabolic rate.
• Kreider RB, et al. Effects of Coleus forskohlii supplementation on body composition and markers of health in sedentary overweight females.
• Experimental Biology 2002 Late Breaking Abstracts. LB305: 2002.
• Seamon KB, Daly JW. Forskolin: a unique diterpene activator of cAMP-generating systems. J Cyclic Nucleotide Res. 1981;7:201–224.
• Laurenza A, Sutkowski EM, Seamon KB. Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action? Trends Pharmacol Sci. 1989;10:442–447.
• Marone G, Columbo M, Triggiani S, et al. Forskolin inhibits the release of histamine from human basophils and mast cells. Agents Actions. 1986;18:96–99.
• Ammon HPT, Muller AB. Forskolin: from an Ayurvedic remedy to a modern agent. Planta Med. 1985:473–477.
• DeSouza NJ. Industrial development of traditional drugs: the forskolin example. A mini-review. J Ethnopharmacol. 1993;38:177–180.
• Bronchodilatory and antiallergy activity of forskolin. Eur J Pharmacol. 1985;111:1–8.
• Schlepper M, Thormann J, Mitrovic V. Cardiovascular effects of forskolin and phosphodiesterase-III inhibitors. Basic Res Cardiol. 1989; 84(suppl 1):197–212.
• Voir Monographie du Gouvernement du Canada.http://www.hc-sc.gc.ca/hpfb-dgpsa/nhpd-dpsn/mono_calcium_f.html
• Badmaev V, Majeed M, Conte AA. Garcinia cambogia for weight loss. JAMA. 1999 Jul 21;282(3):233-4; discussion 235.
• Firenzuoli F, Gori L. Garcinia cambogia for weight loss. JAMA. 1999 Jul 21;282(3):234; discussion 235.
• Heymsfield SB, Allison DB, Vasselli JR, Pietrobelli A, Greenfield D, Nunez C. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA. 1998 Nov 11;280(18):1596-600.
• McCarty MF. Inhibition of citrate lyase may aid aerobic endurance. Med Hypotheses. 1995 Sep;45(3):247-54.
• McCarty MF. Utility of metformin as an adjunct to hydroxycitrate/carnitine for reducing body fat in diabetics. Med Hypotheses. 1998 Nov;51(5):399-403.
• Van Loon LJ, van Rooijen JJ, Niesen B, Verhagen H, Saris WH, Wagenmakers AJ. Effects of acute (-)-hydroxycitrate supplementation on substrate metabolism at rest and during exercise in humans.Am J Clin Nutr. 2000 Dec;72(6):1445-50.
• Lim K, Ryu S, Ohishi Y, Watanabe I, Tomi H, Suh H, Lee WK, Kwon T. Short-term (-)-hydroxycitrate ingestion increases fat oxidation during exercise in athletes.J Nutr Sci Vitaminol (Tokyo). 2002 Apr;48(2):128-33.
• Mattes RD, Bormann L. Effects of (-)-hydroxycitric acid on appetitive variables. Physiol Behav. 2000 Oct 1-15;71(1-2):87-94.
• Westerterp-Plantenga MS, Kovacs EM. The effect of (-)-hydroxycitrate on energy intake and satiety in overweight humans.Int J Obes Relat Metab Disord. 2002 Jun;26(6):870-2.
• Kovacs EM, Westerterp-Plantenga MS, de Vries M, Brouns F, Saris WH. Effects of 2-week ingestion of (-)- hydroxycitrate and (-)-hydroxycitrate combined with medium-chain triglycerides on satiety and food intake.Physiol Behav. 2001 Nov-Dec;74(4-5):543-9.
• Kovacs EM, Westerterp-Plantenga MS, Saris WH. The effects of 2-week ingestion of (--)-hydroxycitrate and (--)-hydroxycitrate combined with medium-chain triglycerides on satiety, fat oxidation, energy expenditure and body weight. Int J Obes Relat Metab Disord. 2001 Jul;25(7):1087-94.
• Lenz TL, Hamilton WR. Supplemental products used for weight loss.J Am Pharm Assoc (Wash DC). 2004 Jan-Feb;44(1):59-67; quiz 67.
• Heymsfield SB, Allison DB, Vasselli JR, Pietrobelli A, Greenfield D, Nunez C. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA. 1998 Nov 11;280(18):1596-600.
• Preuss HG, Bagchi D, Bagchi M, Rao CV, Dey DK, Satyanarayana S. Effects of a natural extract of (-)- hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. Diabetes Obes Metab. 2004 May;6.
• Barnes J, Anderson LA, Phillipson JD. Herbal Medicines: A guide for healthcare professionals. 2nd ed. London (UK): Pharmaceutical Press; 2002.
• Briggs CJ. Evening Primrose. Rev Pharm Canad 1986;119:249-54.
• Brinker F. Herb Contraindication and Drug Interactions. 3rd edition. Sandy (OR): Eclectic Medical Publications;2001.
• Horrobin DF. Gammalinolenic acid: an intermediate in essential fatty acid metabolism with potential as an ethical pharmaceutical and as a food. Rev Contemp Pharmacother 1990; 1:1-45.
• The Gamma Linolenic Acid Multicentre Trial Group. Treatment of diabetic neuopathy with gamma-linolenic acid. Diabetes Care;16:8-15.
• Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H. Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty.Phytomedicine. 2000 Oct; 7(5): 365-71.
• Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated lowdose regimen. Phytomedicine. 2000 Apr;7(2):85-9.
• Shevtsov VA, Zholus BI, Shervarly VI, Vol'skij VB, Korovin YP, Khristich MP, Roslyakova NA, Wikman G. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work.Phytomedicine. 2003 Mar; 10(2-3): 95-105.
• Brown RP, Gerbarg PL, Ramazanov Z. Rhodiola rosea: A Phytomedicinal Overview. HerbalGram. 2002;56:40-52. American Botanical Council, États-Unis, 2002.
• Murakami C, Myoga K, Kasai R, Ohtani K, Kurokawa T, Ishibashi S, Dayrit F, Padolina WG, Yamasaki K. Screening of plant constituents for effect on glucose transport activity in Ehrlich ascites tumour cells. Chem Pharm Bull (Tokyo). 1993 Dec;41(12):2129-31.
• Suzuki Y, Unno T, Ushitani M, Hayashi K, Kakuda T. Antiobesity activity of extracts from Lagerstroemia speciosa L. leaves on female KK-Ay mice. J Nutr Sci Vitaminol (Tokyo). 1999 Dec;45(6):791-5.
• Kakuda T, Sakane I, Takihara T, Ozaki Y, Takeuchi H, Kuroyanagi M. Hypoglycemic effect of extracts from Lagerstroemia speciosa L. leaves in genetically diabetic KK-AY mice. Biosci Biotechnol Biochem. 1996 Feb;60(2):204-8.
• Hayashi T, Maruyama H, Kasai R, Hattori K, Takasuga S, Hazeki O, Yamasaki K, Tanaka T., Ellagitannins from Lagerstroemia speciosa as activators of glucose transport in fat cells, Planta Med. 2002 Feb;68(2):173-5.
• Voir Monographie du Gouvernemetn du Canada http://www.hc-sc.gc.ca/hpfb-dgpsa/nhpd-dpsn/mono_cayenne_f.html
• Johnston L, Reiss Reynolds H, Patz M, et al. Cholesterol-lowering benefits of a whole grain oat ready-to-eat cereal. Nutr Clin Care, 1998; 1:6-12.
• Jenkins DJA, Kendall CWC, Vuskan V, et al. Soluble fibre intake at a dose approved by the US Food and Drug Administration for a claim of health benefits: serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial "métabolisme"
• Encyclopédie Microsoft® Encarta® en ligne 2005 http://fr.encarta.msn.com © 1997-2005 Microsoft Corporation. Tous droits réservés.

• For people wishing to obtain the maximum action of Metabotonik, use D-Toxi which is conceived to cleanse the system (detoxification cure);

• If Metabotonik is used for weight loss and thus accompanied by a food diet, it would be preferable to combine this product with Minero-Balance, Vita-Balance Man or Vita-Balance Woman , according to the situation, in order to avoid deficiencies;

• Metabotonik may be combined with Blitz in order to have enough energy during a weight loss diet.