Standardization

Plant / Ingredient	Standardization	Dry plant qty per 7,5 ml
Bio Green Tea	Polyphenols 5 %	600 mg (leaves)
Cat’s Claw	Alcaloides 0.5 %	400 mg (bark)
Bio Rosemary	Quercetine 2 %	400 mg (leaves)
Onion	N/A	300 mg (vegetable)
Noni	Polysaccharides 1 %	300 mg (fruits)
Bio Acerola	Ascorbic Acid 5 %	200 mg (fruits)
Bio Pomegranate	Ellagic Acid 4 %	100 mg (seeds)

Pharmacological activity

Recognized traditional use.

 

GREEN TEA (Camellia sinensis)

Origin: Asia

• Antioxidant and cellular protector;
• Cardiovascular protector;
• Helps to prevent the apparition of cancerous cells.

 

CAT’S CLAW (Uncaria tomentosa)

Origin: South America

• Immunomodulator and antioxidant;
• Antiradicular and antibacterial.

ONION (Allium cepa)

Origin: Canada

• Antioxydant and antiradicular.

 

ROSEMARY (Rosmarinus officinalis)

Origin: Canada

• Antioxydant;
• Toxin eliminator.

 

NONI (Morinda citrifolia)

Origin: Polynesia

• Facilitates digestion;

• Antioxidant and energy tonic.

 

ACEROLA (Malpighia glabra)

Origin: Latin America

• Source of Vitamin C;
• Antioxidant, anti-aging.

 

POMEGRANATE (Punica granatum)

Origin: Europe

• Antioxidant and antiradicular;
• Source of Vitamin C.

AntiOxy Bio may be used the following way:

•  For an annual cure or when oxidation symptoms are observed (degenerative diseases, premature aging, in presence of an important stress, etc.), take 1½ teaspoon (7,5 ml) twice a day.

• Premature signs of the aging process;
• Degenerative diseases, cataracts and allergies;
• Chronic tiredness and stress;
• Chronic diseases that decrease the immune defence.

• Live in a polluted environment;
• Smoke, consume alcohol and drugs, etc.;
• Are in contact with pesticides, etc.

CONTRAINDICATIONS

• Allergy to the ingredients of this formulation;
• Serious disease or while taking another drug;
• Autoimmune diseases;
• Digestion or urination disorders, diabetes, impaired renal or hepatic functions.

PRECAUTIONS

• In the event of an overdose (more than 4 times the amount recommended): May cause diarrhea, abdominal cramps, constipation and cephalgias. Stop use in the event of oversensitivity;
• Cease the use and consult a health practitioner if the symptoms persist or if undesirable effects should occur;
• Avoid giving to children under 3 years of age or in the case of a pregnancy or breast-feeding;
• Do not give to epileptics.

SPEED OF THE EFFECT

AntiOxy Bio acts over time. According to the degree of damage due to oxidation, an improvement could be observed from 2 to approximately 6 weeks from starting therapy. In less than two weeks, the person who is receiving therapy can already feel an increase in total energy.
For a specific disease, it can take more time, since the damage due to oxidation takes time to undo. However, the improvement will last longer.

SYNERGISTIC ACTION

The use of a supplement made up of multiple antioxidants is more effective to counter the effect of a high rate of oxidation than the use of just one antioxidant. Each antioxidant acts in different ways. Some act more effectively on the circulatory system, others on neurotransmission and others on the process of ageing. They can act on several levels in the oxidation of various enzymes. This is why it is so important to combine them, in order to obtain a complete spectrum of action. This is to maximize the effects on the fatty acids, the vitamins and the bioflavonoïdes that they were combined with some antioxidant plants.
We studied well and identified the plants contained in AntiOxy Bio for their antioxidant effects. For example, green tea, as well as other exotic plants, such as noni and several others which are not yet sufficiently known. Each plant has its own active molecule which acts synergistically. The family of epicatechines or various acids (such as carnosic and lipoidic acid); the enzymes and the minerals are present in significant quantities in order to improve the action of the product.
All these plants have in common the components belonging to the class of polyphenols (flavonoids or non-flavonoids). At the time of the congress of Vichy in November of 2003, on polyphenols and its relations to health, several researchers had the results of their research in the field. It was proven that polyphenols:

• Intervene in the inhibition of the mechanism of oxidation of bad cholesterol and thus prevented arterial obstruction;
• Can prevent the formation of cancerous tumors by preventing the formation of the agents which cause harmful genetic mutations;
• Can also neutralize the free radicals directly (antiradical action) and inhibit the oxidation of lipids (lipoxygenase action);
• Limit the platelet aggregation used in the phenomenon of coronary thrombosis (formation of clots in the arteries).

THERAPEUTIC EFFECTS

The immediate benefits can be felt in less than one half hour.

Antioxidant effect: AntiOxy Bio is a cleanser of free radicals and can:

• Increase vitality;
• Improve the circulatory system by supporting it and by neutralizing free radicals in the blood circulation. This product prevents the accumulation of free radicals and protects the integrity of blood vessel walls. It is noticed that it reinforces them and support blood circulation. You can expect an effect on blood pressure and on the superficial blood vessels such as varicose veins and rosacea (blotches);
• Protect the joints and help decrease bone degeneration;
• We can observe improvements in the memory and vision processus following treatment.

Long-term effects:

• Help to decrease the symptoms of allergies by decreasing the formation of histamine, the molecule responsible for allergic reactions;
• Healthy skin: One can envision an improvement in the elasticity and softness of the skin during the process of ageing. It will seem younger. AntiOxy Bio can also be useful for psoriasis;
• Increase immune-response to fight infections.

Q: Is oxidation so dangerous?

• Ali M, et al. A potent thromboxane inhibitor in green tea. Prostaglandins Leukot Essent Fatty Acids. 1990; 40:281-283.

• Fujiki H, Suganuma M, Okabe S, et al. Mechanistic findings of green tea as cancer preventive for humans. Proc Soc Exp Biol Med. 1999; 220(4): 225-228.

• Hasegawa R, Takekida K, Sai K, et al. Inhibitory effect of green tea infusion of hepatotoxicity [in Japanese]. Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku. 1998;(116): 82-91.

• Shim JH, Kang MG, Kim YH, Roberts C, Lee IP. Chemopreventive effect of green tea (Camellia sinensis) among cigarette smoke. Cancer- Epidemio-Biomarkers-Prev. 1995;Jun; 4(4): 387-91.

• Shiota S, Shimizu M, Mizushima T, Ito H, et al. Marked reduction in the minimum inhibitory concentration (MIC) of ß-lactams in methicillinresistant Staphylococcus aureus produced by epicatechin gallate, an ingredient of green tea (Camellia sinensis). Biol. Pharm. Bull. 1999; 22(12): 1388-1390.

• Sirving K. Drinking black tea may cut risk of stroke. AMA Arch Intern Med. March 25, 1998.

• Tamozawa H, et al. Natural antioxidants I. Antioxidant components of tea leaf (Thea sinensis L.). Chem Pharm Bull. 1984; 32: 2011 2014.

• Voir monographie du Gouvernement du Canada. http://www.hc-sc.gc.ca/hpfb-dgpsa/nhpd-dpsn/mono_rosemary_f.html

• Blumenthal M, Busse WR, Goldberg A, Gruenwald J, Hall T, Riggins CW, Rister RS, editors. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin (TX): American Botanical Council; 1998.

• Brinker F. Herb Contraindications and Drug Interactions. 3rd ed. Sandy (OR): Eclectic Medical Publications; 2001.

• Alternative Medicine Foundation. Noni, HerbMed. http://www.herbmed.org.

• Wang MY, West BJ, Jensen CJ, Nowicki D, Su C, Palu AK, Anderson G. Morinda citrifolia (Noni): A literature review and recent advances in Noni research. Acta Pharmacol Sin 2002 Dec; 23(12): 1127-41. Texte complet accessible à l'adresse suivante: http://www.chinaphar.com

• Sang S, He K, Liu G, Zhu N, Cheng X, Wang M, Zheng Q, Dong Z, Ghai G, Rosen RT, Ho CT. A new unusual iridoid with inhibition of activator protein-1 (AP-1) from the leaves of Morinda citrifolia L.Org Lett 2001 May 3; 3(9): 1307-9.

• Sang S, Cheng X, Zhu N, Wang M, Jhoo JW, Stark RE, Badmaev V, Ghai G, Rosen RT, Ho CT. Iridoid glycosides from the leaves of Morinda citrifolia. J Nat Prod 2001 Jun; 64(6): 799-800.

• Saludes JP, Garson MJ, Franzblau SG, Aguinaldo AM. Antitubercular constituents from the hexane fraction of Morinda citrifolia Linn. (Rubiaceae). Phytother Res 2002 Nov; 16(7): 683-5.

• Hirazumi A, Furusawa E. An immunomodulatory polysaccharide-rich substance from the fruit juice of Morinda citrifolia (noni) with antitumour activity. Phytother Res 1999 Aug; 13(5): 380-7.

• Leung. A., Foster, S. Encylopedia of Common Natural Ingredients, (1996) ed. Wiley & Sons, NY, NY. 1996

• Duke, J.A., Phytochemical Database, Agricultural Research Service, USDA

• Leme J Jr, et al. [Variation of ascorbic acid and beta-carotene content in lyophilized cherry from the West Indies (Malpighia punicifolia L.)]

• Arch Latinoam Nutr, 1973 Jun Medeiros RB de. [Proportion of ascorbic, dehydroascorbic and diketogulonic acids in green or ripe acerola (Malpighia punicifolia)] Rev Bras Med, 1969 Jul

• Aviram M, Rosenblat M, Gaitini D, Nitecki S, Hoffman A, Dornfeld L, Volkova N, Presser D, Attias J, Liker H, Hayek T. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clinical Nutrition, Juin 2004, Vol. 23, No 3, 423-33.

• Aviram M, Rosenblat M, Billecke S, Erogul J, Sorenson R, Bisgaier CL, Newton RS, La Du B. Human serum paraoxonase (PON 1) is inactivated by oxidized low-density lipoprotein and preserved by antioxidants. Free Rad Biol Med, Avril 1999. Vol.26, No 7-8, 892-904.

• J Ethnopharmacol. 2003 Dec; 89(2-3): 295-300. Studies on the toxicity of Punica granatum L. (Punicaceae) whole fruit extracts.
  
• Vidal A, Fallarero A, Pena BR, Medina ME, Gra B, Rivera F, Gutierrez Y, Vuorela PM. Department of Biochemistry, Faculty of Biology, University of Havana, Havana, Cuba. alvido@yahoo.com PMID: 14611895 [PubMed - indexed for MEDLINE]

• Aviram M, Dornfeld L, Kaplan M, et al. Pomegranate juice flavonoids inhibit low-density lipoprotein oxidation and cardiovascular diseases: studies in atherosclerotic mice and in humans. Drugs Exp Clin Res. 2002; 28(2-3): 49-62. Review.

• Aviram M, Dornfeld L, Rosenblat M et al. Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice. Am J Clin Nutr. 2000 May; 71(5) :1062-76.

• Aviram M, Rosenblat M, Gaitini D, et al. Pomegranate Juice Improves Carotid Artery Health and Lowers Blood Pressure in Patients with Carotid Artery Stenosis. American Botanical Council, 2005; 65: 28-30. Herbalgram.org

• Sandoval M, &al Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content. Phytomedicine 2002 May; 9(4):325-37.

• Piscoya J, Rodriguez Z, Bustamante SA, Okuhama NN, Miller MJ, Sandoval M. Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis. Inflamm Res 2001 Sep; 50(9): 442-8.

• Sheng Y, Li L, Holmgren K, Pero RW. Related Articles, Links DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study. Phytomedicine. 2001 Jul;8(4): 275-82. PMID: 11515717 [PubMed - indexed for MEDLINE]

• Sandoval M, Okuhama NN, Zhang XJ, Condezo LA, Lao J, Angeles' FM, Musah RA, Bobrowski P, Miller MJ. Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content. Phytomedicine. 2002 May;9(4):325-37.
  

• Helen A, & al Antioxidant effect of onion oil (Allium cepa. Toxicol Lett 2000 Jul 27;116(1-2):61-8.Jaradeh SS, Prieto TE, Lobeck LJ.

• Progressive polyradiculoneuropathy in diabetes: correlation of variables and clinical outcome after immunotherapy. J Neurol Neurosurg Psychiatry. 1999 Nov; 67(5): 607-12.